Find updates about our newest products and features, and articles highlighting flow and pressure related applications, discoveries, and advancements.
Introduction to hydrogen fuel cells Hydrogen fuel cells are a clean, emissions-free alternative to traditional combustion processes, and use hydrogen to generate energy via electrochemical reactions. These cells are made even more environmentally friendly when the hydrogen is produced via sustainable means. There are many variations in fuel cell technology, but they share similar features. […]
13 tools to use when planning for pharma scale-up 1. Plan for FDA approvals Only 12% of drugs that make it from the lab and into phase 1 clinical trials end up receiving FDA approval. However, planning for eventual pharma scale-up long before you receive approvals allows you to achieve commercial-scale production in the quickest […]
Should I switch to single-use bioreactors? Ten years ago, single-use bioreactor (SUB) vessels were limited in size, making them only practical for lab setups. However, Thermo Scientific is launching a 5,000 L single-use bioreactor and BioInno is already using a 6,000 L reactor. These reactors have much higher titers than even multiuse equipment did ten […]
Comparing the environmental impacts of single-use bioreactors vs. stainless steel Single-use plastics for consumer products have long been the bane of the environmental movement, with grocery bags and straws as obvious examples. Single-use plastics in bioprocessing, however, provide significant environmental advantages compared to the stainless steel alternatives. In addition to providing pharmaceutical companies with flexible, […]
Using fewer flow controllers for increased redundancy in bioreactor systems When uptime is crucial, redundancy can be built into systems to increase reliability and availability. Redundancy in bioreactor systems means more uninterrupted hours dedicated to development and production of biologics; and when issues inevitably appear, redundant systems are able to compensate with minimal disruption to […]
Monitor outgassed materials in bioreactor headspace for closed-loop system control Measuring outgassed material in the bioreactor headspace is a powerful tool for understanding the metabolic activity of your cell culture and the effectiveness of your bioreactor setup. While it is more resource intensive than simply measuring dissolved oxygen and pH, outgassing measurements ensure that your […]
Methods of leak checking SUBs to mitigate risk to operators and processes Single-use bioreactors (SUBs) are successfully capturing the attention of researchers and manufacturers, offering notable advantages over traditional bioreactors for their flexibility and lower cost. However, unlike multiuse stainless steel or glass vessels, single-use plastic vessels are susceptible to and must be checked for […]
Five tools to optimize bioreactor production and shorten vaccine development timelines Immunotherapy for cancer, autoimmune, or neurological diseases requires manufacturing antibodies that bind to and label diseased cells for the body to destroy. Developing the seed strains to grow these antibodies in cell cultures and optimizing the bioreactors and culture growth conditions in the lab […]
Fast global vaccine delivery via reduced bioreactor footprint Global vaccine distribution is critical to the eradication of deadly diseases. In 1980, after an intensive vaccination campaign, the World Health Assembly declared smallpox eradicated. As of 2020, there are fewer than 500 new cases of polio each year in the world. In the United States, 14 […]
Control systems for benchtop bioreactors In the past, successes and failures of large-scale biologics production could largely be attributed to the experience of the operators and their “magic touch” (or lack thereof). This is in stark contrast to Pharma 4.0, and its emphasis on connected, integrated data systems for best control of pharmaceutical manufacturing from […]