This article was originally published in Fluid Handling Pro on June 29, 2021. Read the original article here. Bioreactor sparging systems are designed to introduce oxygen to feed cell cultures while removing carbon dioxide to prevent toxic buildup. Various bioreactor features and components are critical to optimizing these processes. Spargers, impellers, baffling, and bioreactor shape all […]
Single-use bioreactors (SUBs) offer key advantages over reusable bioreactors, including increased sterility and subsequently simpler and faster changeover between batches or campaigns. After the product is removed from the bioreactor, the user can remove the SUB bag from its holding container and dispose of it (generally via incineration). The new vessel can then be installed […]
Evaluation of Alicat mass flow controllers’ resistance to back pressure contamination Mass flow controllers (MFCs) are essential to many modern production and test processes. Precise and reliable flow control is particularly important for efficient, sustainable production in applications such as glass fabrication and bioprocessing. Within such processes, MFCs occasionally face the challenge of encountering unexpected […]
How do you know that your bioprocessing is free from costly leaks or integrity failures? Leak testing of single use systems can now be accomplished easily and quickly with an Alicat Scientific Whisper Series Mass Flow Meter.
Cowritten by Alicat and Chip Stacy, AbbVie Senior Engineer of Digital Systems As the need for potent and specific pharmaceuticals grows, pharmaceutical manufacturers have turned to biologics to meet the increasing needs and find treatments for complex and currently untreatable conditions including cancer and myriad genetic diseases. Biologics and biosimilars differ from conventional small molecule drugs […]
Gasification is a process in which biomass or fossil fuel is converted into carbon monoxide, hydrogen, and carbon dioxide (syngas or synthetic gas).1 According to Carnot’s theorem of thermodynamic efficiency, the syngas produced is more energy-rich than organic fuel in its combustion due to higher combustion temperatures. Furthermore, syngas can be used directly in gas […]
With protocols for bioprocessing firmly established, there is an increasing focus on reducing the cost of producing biologics, biosimilars, mABs, and other modern medicines requiring bioreactions. Producing these pharmaceuticals promises to revolutionize treatment of many difficult diseases, especially modern scourges that have been resistant to small molecule-based therapies. Focus on cost reduction and improved speed […]
Many pharmaceutical and agricultural products, biofuels, and biochemicals are produced in a fermentation process similar to the way beer is made. Biotech and chemical research companies that make such products need to accurately control the amount of each gas that is fed into the process. One such company is ILS Automation, specializing in OEM and […]