Blog

Tag: Bioreactor

  • Livestock in field
    Native Microbials makes livestock lives better, more productive, and more sustainable

    Native Microbials makes livestock lives better, more productive, and more sustainable The microbiome discovery company Native Microbials has studied the highest-performing livestock and teased out impactful, natively-derived organisms to enable all livestock to perform better. We spoke with Martin Mayhew, Vice President of Process Development and Manufacturing. It has been “really interesting to see this […]

  • What is mass flow?

    What is mass flow? Most Alicat devices measure and control the mass flow rate of a gas. As gas flows through an Alicat, it passes through a flow channel with temperature and pressure sensors. These sensors measure the instantaneous temperature and pressure of the gas stream, and use that information in combination with known gas […]

  • mfc bioprocessing flow control
    Addressing scaling challenges of bioreactor sparging using mass flow control

    Addressing scaling challenges of bioreactor sparging using mass flow control This article was originally published in Fluid Handling Pro on June 29, 2021. Read the original article here. Bioreactor sparging systems are designed to introduce oxygen to feed cell cultures, while removing carbon dioxide to prevent toxic buildup. Various bioreactor features and components are critical to […]

  • Flexboy single use bag
    Inflating single-use bioreactor bags using dual-valve pressure controllers

    Inflating single-use bioreactor bags using dual-valve pressure controllers Single-use bioreactors (SUBs) offer key advantages over reusable bioreactors, including increased sterility and subsequently simpler and faster changeover between batches or campaigns. After the product is removed from the bioreactor, the user can remove the SUB bag from its holding container and dispose of it (generally via […]

  • Alicat mass flow controllers resist back pressure contamination

    Evaluation of Alicat Mass Flow Controllers’ Resistance to Back Pressure Contamination Mic Chaudoir, Ph.D. Rohan Morajkar, Ph.D. Introduction Mass flow controllers (MFCs) are essential to many modern production and test processes. Precise and reliable flow control is particularly important for efficient, sustainable production in applications such as glass fabrication and bioprocessing. Within such processes, MFCs […]

  • Flexboy single use bag
    Accurate and simplified pressure decay leak testing for single-use bioprocessing

    How do you know that your bioprocessing is free from costly leaks or integrity failures? Leak testing of single use systems can now be accomplished easily and quickly with an Alicat Scientific Whisper Series Mass Flow Meter.

  • Selection guide: Alicat mass flow instruments for bioprocessing

    Selection guide: Alicat mass flow instruments for bioprocessing Alicat Scientific mass flow meters and controllers are highly configurable – during our last count, we lost track at 1034 configurations. This gives our customers and partners the ability to customize their devices to meet specific application needs. For bioprocessing applications, this includes specified bioreactor mass flow […]

  • Tech comparison: Alicat flow meters vs rotameters for bioprocessing

    Tech comparison: Alicat flow meters vs rotameters for bioprocessing Any bioprocess needs flow meters to feed bioreactors, drive filtration and chromatography, and monitor critical process parameters. Here we provide a comparison of the operating principles and key features of two flow meter technologies: rotameters and Alicat mass flow meters. We then provide recommended use cases […]

  • More efficient flow control for bioreactors and bioprocess systems

    More efficient flow control for bioreactors and bioprocess systems Mic Chaudoir, Ph.D. Chip Stacy, AbbVie Senior Engineer of Digital Systems As the need for potent and specific pharmaceuticals grows, pharmaceutical manufacturers have turned to biologics to meet the increasing needs and find treatments for complex and currently untreatable conditions including cancer and myriad genetic diseases. Biologics […]

  • Bioprocessing equipment certifications for elastomeric components

    Bioprocessing equipment certifications for elastomeric components The American Society of Mechanical Engineers (ASME) periodically publishes standards which lead to recommendations for bioprocessing equipment certifications, with the latest edition published in 2016 (BPE-2016). These standards clearly recommend that only certain materials be used in bioprocessing to ensure that biologic and drug products are not contaminated and can […]