Bio-Series: Mass Flow Meters for Bioreactors and Fermenters

Bio-Series Meters are designed for scalable mass flow measurement in bioreactors and fermenters, with industry-leading reliability and communication protocols for easy integration into your existing system.
  • Stable. Long-term measurement stability due to extremely low zero drift.
  • Robust, compliant materials. Resistance to process water contamination with a lifetime warranty and available IP66 ingression. ASME-recommended materials available including 316L stainless steel and USP Class VI FDA-grade certified elastomers.
  • Flexible. Minimized footprint and piping via gas select feature enabling exchange of CO2, Air, O2, N2, or over 100 other gases without re-calibration or loss of accuracy, and a 10,000:1 operating range.
  • Backlit display. Monitor process with a high-contrast color display.

Alicat’s experience in process stages from benchtop R&D through GMP production of biologics and biosimilars ensure robust solutions that will scale with your development.

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Accessories included with purchase

Device specs and customization options

Device Overview

Bio-Series meters are designed for scalability, data compatibility, and ease of use. Upgrade your manual systems to monitor mass flow with higher-precision. Alicat devices are available in a wide range of flow rates and are highly customizable for smooth integration into your existing setup or system.

  • All standard flow rates. Low flow devices range from 1–5 SCCM. Mid flow devices range from 10 SCCM–20 SLPM. High flow devices range from 20-500 SLPM.
  • Communication protocols. Designed for seamless compatibility, Alicat offers a full complement of available protocols: RS-232/analog, RS-485/analog, Modbus RS-232, Modbus RS-485, Modbus TCP/IP, PROFIBUS, Ethernet/IP, DeviceNet RS-232, EtherCAT, and PROFINET.
  • Process connections. Standard SAE or NPT connectors.
Device Ranges and Full Specs

Devices are custom ranged from 1 SCCM full scale to 500 SLPM full scale with measurement ranges of 0.01% to 100% of full scale.

Wetted Materials

Bioreactors and fermenters require very low outgassing from wetted materials to ensure products are free from unwanted contaminants.

  • Wetted materials: USP Class VI elastomers with 316L Stainless Steel flow bodies. Devices with stainless steel valves are available on request.

Not exactly what you’re looking for?

  • Check out our Bio-Series controller.
  • For bioprocessing applications that do not require ASME BPE-2016 compliant materials, the standard series mass flow meters and controllers are designed for a wide range of flows with unparalleled precision and accuracy.
  • Interested in gas mixing with mass flow controllers for bioreactors? Fusion Flow‘s modular gas mixing system is designed for seamless integration into existing systems.

Our expert team of applications engineers is available to provide additional information, discuss your application, or answer any questions you may have.

Contact an applications engineer

Optimizing bioreactor production

Bioreactors are used in a growing number of applications, from producing bio-adaptive medicines or environmentally friendly fertilizers and pesticides, to brewing beer, refining ethanol and treating wastewater. The increase in biologics production and single use reactors has led to a need for even greater precision and flexibility in instrumentation.

High flow control for gasification

Alicat Scientific mass flow controllers can be used in multiple areas of the gasification process: combustion, clean-up reactors, safety, and quality control. Get more precise syngas production, redundancy between units and extremely fast control. Alicat’s MCR controllers use near-frictionless Rolamite proportional control valves to rapidly and precisely control flow rates up to 5000 slpm. With accuracy of ±(0.8% of reading + 0.2% of full scale range) to high flow rates, precise composition can be ensured.

Lowered cost and increased speed for biologics production

With protocols for bioprocessing now firmly established, there is an increasing focus on reducing the cost of producing biologics, biosimilars, mABs and other modern medicines that require bioreactions and current trends toward single use bioreactors. You can reduce your cost per run and extend your processes with Alicat’s mass flow accuracy as low as 0.1% of full scale and unbeatable repeatability of ±0.02% of full scale readings.

Aerobic vs. anaerobic wastewater treatment: an overview

Bioreactors are now a common part of wastewater treatment. Alicat’s revolutionary differential-pressure based mass flow controllers allow for extreme flexibility in mass flow control and the response times needed to make this process efficient and cost effective.

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