Mass Flow Controllers & Meters


BIO Series Mass Flow Controllers & Meters for Bioprocessing

Unmatched reliability, extreme flexibility and precise measurements in the world’s only mass flow controller for bioprocessing


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Experience the Alicat difference – where modern design and solid state construction provide solutions for many applications. Alicat, the world’s fastest flow controller company, now offers the first mass flow controllers built specifically for the needs of bioprocessing professionals – the BIO series: Proven Mass Flow Performance for Bioprocess & Bioreactor Applications. These units are designed specifically for professional engineers involved in bioreactor construction and upstream or downstream processes. They offer the highest reliability in the industry with an unprecedented lifetime warranty and resistance to in-line water contamination.

Reliable, Adaptable and Compatible Flow Control

  • Extremely low zero drift ensures long term measurement stability
  • Resistance to process water contamination with a lifetime warranty
  • High contrast ultra-sharp color display
  • ASME recommended materials including 316L stainless steel and USP Class VI FDA-grade certified elastomers
  • Gas Select feature enables exchange of CO2, Air, O2, N2 or over 100 other gasses without re-calibration or loss of accuracy
  • Drive Display for monitoring of in-line process health and control performance
  • IP66 ingression protection option available

Flexible Configuration, Customized for Your Needs

  • Built with your preferred industrial protocols and Pharma 4.0 in mind
  • Upgrade manual systems, such as rotameters, to higher precision controlled and monitored mass flow
  • Wide range of flow rates – from 1SCCM up to 5000SLPM
  • Controllable ranges exceeding 10,000:1 eliminate the need for multiple gas lines
  • Ultra-fast 10ms response times enable high speed data logging and control
  • On-site calibration tools available – Never return a unit
  • Flexible process connections (SAE standard)

Wide range flow rates and compatibility with multiple gasses eliminates unnecessary piping

  • 10-50 SLPM
  • 50-200 SLPM
  • 200 – 1,000 SLPM

FDA-grade elastomers prevent contamination

Backflow tolerance with zero calibration drift

316L stainless steel for durability and stability, with a lifetime warranty


Optimizing Bioreactor Production

Bioreactors are used in a growing number of applications, from producing bio-adaptive medicines or environmentally friendly fertilizers and pesticides, to brewing beer, refining ethanol and treating wastewater. The increase in biologics production and single use reactors has led to a need for even greater precision and flexibility in instrumentation.

Elastomer Considerations for Bioreactors

Biocompatible wetted materials are important to avoid contamination. At Alicat Scientific, we are very aware of the need to prevent contamination of the fragile bioprocessing ecosystem. Including importance of appropriate wetted materials, minimal outgassing and products free from contamination. Alicat BIO Series flow meters and controllers, can help ensure that fast, precise and uncontaminated flow is always in your process.

High Flow Control for Gasification

Alicat Scientific Mass Flow Controllers can be used in multiple areas of the gasification process: combustion, clean-up reactors, safety, & quality control. Get more precise syngas production, redundancy between units and extremely fast control. Alicat’s MCR controllers with near-frictionless Rolamite proportional control valves- rapidly & precisely control flow rates up to 5000 SLPM. With accuracy of +/- (0.8% of reading + 0.2% of full scale range) to high flow rates, precise composition can be ensured.

Lowered Cost and Increased Speed for Biologics Production

With protocols for bioprocessing now firmly established, there is an increasing focus on reducing the cost of producing biologics, biosimilars, mABs and other modern medicines that require bioreactions and current trends toward single use bioreactors. You can reduce your cost per run and extend your processes with Alicat’s astonishing mass flow accuracy as low as .1% of full scale and unbeatable repeatability of +/- .02% of full scale readings.

Aerobic vs Anaerobic Wastewater Treatment: An Overview

Bioreactors are now a common part of wastewater treatment. Alicat’s revolutionary differential-pressure based mass flow controllers allow for extreme flexibility in mass flow control and the response times needed to make this process efficient and cost effective.

Communications Protocols:

RS 485/Analog
Modbus over 232/Analog
Modbus over 485/Analog
Profibus via RS-485
Ethernet IP
DeviceNet + RS-232
Modbus TCP/IP

See Product Spec Sheets For Full Specs

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