{"id":41732,"date":"2021-05-31T08:26:00","date_gmt":"2021-05-31T08:26:00","guid":{"rendered":"https:\/\/www.alicat.com\/?p=41732"},"modified":"2025-09-25T20:54:28","modified_gmt":"2025-09-25T20:54:28","slug":"einweg-bioreaktoren","status":"publish","type":"post","link":"https:\/\/www.alicat.com\/de\/articles\/single-use-bioreactors\/","title":{"rendered":"Vorteile von Einweg-Kunststoff-Bioreaktoren f\u00fcr die Bioprozessierung im kleinen Ma\u00dfstab"},"content":{"rendered":"

[et_pb_section fb_built=”1″ _builder_version=”4.24.2″ _module_preset=”default” custom_css_free_form=”@media (max-width: 375px) {|| .et-db #et-boc .et-l .et_pb_post_content_0_tb_body {|| width:100% !important;|| }}” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”2em||0px||false|false” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_heading title=”Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing” _builder_version=”4.27.4″ _module_preset=”default” custom_css_free_form=”selector h1 {|| text-wrap: pretty;||}” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_divider color=”#2A3B47″ divider_weight=”2.5px” _builder_version=”4.27.4″ _module_preset=”default” height=”0px” custom_margin=”3rem||3rem||true|false” global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_divider][\/et_pb_column][\/et_pb_row][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_padding=”0px||0px||true|false” locked=”off” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_column type=”4_4″ _builder_version=”4.27.4″ _module_preset=”default” global_colors_info=”{}” theme_builder_area=”post_content”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]Single‑use bioreactors (SUBs) offer an unprecedented level of flexibility to researchers and manufacturers. SUBs are made of plastic, and are incinerated after use rather than put through the CIP\/SIP cycles required by traditional, stainless steel bioreactors. Advantages of single‑use plastic bioreactors are discussed here.[\/et_pb_text][et_pb_heading title=”Increased purity and sterility mean more uptime” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]Single\u2011use vessels come sealed with impellers and spargers already installed<\/a>. They do not need to be autoclaved before use, and can be installed directly into the outer support container.<\/p>\n

Single\u2011use bioreactors are also not subject to in\u2011line sterilization. This saves time while essentially eliminating the risk of cross\u2011contamination between batches. This gives facilities the ability to quickly and easily switch between cell lines and product batches without worrying about purity.[\/et_pb_text][et_pb_heading title=”Lower costs are distributed throughout the lifetime” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]<\/p>\n

SUBs drastically reduce capital expenditures. Single\u2011use plastic vessels are significantly cheaper than integrated stainless steel or glass vessels. Lifetime operating costs are also much lower than for traditional reactors, even accounting for recurring purchases of disposable components.<\/p>\n

Perhaps most impactful, eliminating clean\u2011in\u2011place (CIP) procedures increases the available uptime of the reactor without sacrificing purity. This improves the return on investment for the reactor by greatly improving development and production speed.<\/p>\n

[\/et_pb_text][et_pb_heading title=”Increased flexibility allows for easier experimentation” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]A single‑use bioreactor has a much larger operating range than do multiuse reactors, meaning a single vessel may be appropriate for a large variety of batch sizes. This allows for simpler experimentation and scale‑up than was previously available.<\/p>\n

Additionally, vessels are no longer subject to the design constraints<\/a> imposed by stainless steel, making them more innovative and versatile. For example, cubical designs allow for smaller footprints (and saved bench space) while providing natural baffles. The square vessels are easier to protect during packaging and shipping and are simpler to install.[\/et_pb_text][et_pb_heading title=”Environmental benefits result from single-use” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]Quite counterintuitively, SUBs are generally considered to be more environmentally friendly<\/a> than traditional bioreactors. While SUBs rely on disposable plastics, manufacturing plastics requires significantly less energy than manufacturing stainless steel, accounting for repeated production of the plastic vessels.<\/p>\n

Single‑use vessels are then disposed of, while multiuse vessels are cleaned. CIP is extremely energy intensive, with wastewater containing harmful acids and detergents that must be neutralized (an additional energy‑intensive process). In contrast, single‑use components including sensors, tubing, and stirrers are disposed of by incineration, allowing some of the energy to be recovered.[\/et_pb_text][et_pb_heading title=”Is this the end of multiuse reactors?” _builder_version=”4.27.4″ _module_preset=”default” title_level=”h3″ global_colors_info=”{}” theme_builder_area=”post_content”][\/et_pb_heading][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||2rem||false|false” global_colors_info=”{}” theme_builder_area=”post_content”]No! Traditional, multiuse bioreactors still outperform SUBs in a few key areas, the most important of which is the ability to deliver at scale. While batch sizes in cGMP production can easily reach 10,000 liters, SUBs batch sizes cannot exceed about 2,000 liters. This makes SUBs optimal through research and pilot phases, but drug producers will still need traditional reactors to meet the production demands of large-scale runs.<\/p>\n

That said, SUBs have better sterility, higher product purity, reduced cleaning time, and much lower startup and maintenance costs than traditional bioreactors. Improvements in baffling, impelling, and sparging have all contributed to increasing the maximum batch size and further building out the advantages of single‑use plastic bioreactors. In short, SUBs have delivered on their early promises and are rapidly addressing remaining challenges with new developments in reactor technology.[\/et_pb_text][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” text_font=”|700|||||||” custom_margin=”||2rem||false|false” hover_enabled=”0″ locked=”off” global_colors_info=”{}” theme_builder_area=”post_content” sticky_enabled=”0″]Keep reading: Flow controllers with a 10,000:1 turndown ratio ensure SUB flexibility and scalability. $<\/span><\/a>[\/et_pb_text][\/et_pb_column][\/et_pb_row][\/et_pb_section]<\/p>\n","protected":false},"excerpt":{"rendered":"

Single‑use bioreactors (SUBs) offer an unprecedented level of flexibility to researchers and manufacturers. SUBs are made of plastic, and are incinerated after use rather than put through the CIP\/SIP cycles required by traditional, stainless steel bioreactors. Advantages of single‑use plastic bioreactors are discussed here.Single\u2011use vessels come sealed with impellers and spargers already installed. They do […]<\/p>\n","protected":false},"author":7,"featured_media":39532,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"1400","content-type":"","_searchwp_excluded":"","footnotes":""},"categories":[112],"tags":[],"class_list":["post-41732","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-bioreactors-fermenters"],"acf":[],"yoast_head":"\nAdvantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing - Alicat Scientific<\/title>\n<meta name=\"description\" content=\"Single use plastic bioreactors (SUBs) have become a viable alternative for bioreactor processing. Improved sanitation, lower costs, and more.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.alicat.com\/de\/artikel\/einweg-bioreaktoren\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing\" \/>\n<meta property=\"og:description\" content=\"Single use plastic bioreactors (SUBs) have become a viable alternative for bioreactor processing. Improved sanitation, lower costs, and more.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.alicat.com\/de\/artikel\/einweg-bioreaktoren\/\" \/>\n<meta property=\"og:site_name\" content=\"Alicat Scientific\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/alicatscientific\/\" \/>\n<meta property=\"article:published_time\" content=\"2021-05-31T08:26:00+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-09-25T20:54:28+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/alicat-bioprocessing-2-768x512-1.webp\" \/>\n\t<meta property=\"og:image:width\" content=\"768\" \/>\n\t<meta property=\"og:image:height\" content=\"512\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/webp\" \/>\n<meta name=\"author\" content=\"Alicat Scientific\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Alicat Scientific\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3\u00a0Minuten\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/\",\"url\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/\",\"name\":\"Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing - Alicat Scientific\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/www.alicat.com\\\/wp-content\\\/uploads\\\/2024\\\/04\\\/alicat-bioprocessing-2-768x512-1.webp\",\"datePublished\":\"2021-05-31T08:26:00+00:00\",\"dateModified\":\"2025-09-25T20:54:28+00:00\",\"description\":\"Single use plastic bioreactors (SUBs) have become a viable alternative for bioreactor processing. Improved sanitation, lower costs, and more.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/#breadcrumb\"},\"inLanguage\":\"de\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/#primaryimage\",\"url\":\"https:\\\/\\\/www.alicat.com\\\/wp-content\\\/uploads\\\/2024\\\/04\\\/alicat-bioprocessing-2-768x512-1.webp\",\"contentUrl\":\"https:\\\/\\\/www.alicat.com\\\/wp-content\\\/uploads\\\/2024\\\/04\\\/alicat-bioprocessing-2-768x512-1.webp\",\"width\":768,\"height\":512,\"caption\":\"Bioprocessing mass flow controller\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/articles\\\/single-use-bioreactors\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/www.alicat.com\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#website\",\"url\":\"https:\\\/\\\/www.alicat.com\\\/\",\"name\":\"Alicat Scientific\",\"description\":\"Alicat Scientific | Fastest Flow Measurement Possible\",\"publisher\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/www.alicat.com\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"de\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#organization\",\"name\":\"Alicat Scientific\",\"alternateName\":\"Alicat\",\"url\":\"https:\\\/\\\/www.alicat.com\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"de\",\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"\",\"contentUrl\":\"\",\"caption\":\"Alicat Scientific\"},\"image\":{\"@id\":\"https:\\\/\\\/www.alicat.com\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/alicatscientific\\\/\",\"https:\\\/\\\/linkedin.com\\\/company\\\/alicat-scientific-inc\",\"https:\\\/\\\/www.youtube.com\\\/channel\\\/UCPPX4sBOO2eEu65Zn-EfwCw\"],\"email\":\"info@alicat.com\",\"telephone\":\"+18882906060\",\"legalName\":\"Alicat Scientific, Inc.\"}]}<\/script>\n<!-- \/ Yoast SEO Premium plugin. -->","yoast_head_json":{"title":"Vorteile von Einweg-Kunststoff-Bioreaktoren f\u00fcr die Bioprozessierung im kleinen Ma\u00dfstab - Alicat Scientific","description":"Einweg-Bioreaktoren aus Kunststoff (SUBs) sind zu einer praktikablen Alternative f\u00fcr die Bioreaktorbearbeitung geworden. Bessere Hygiene, niedrigere Kosten und mehr.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.alicat.com\/de\/artikel\/einweg-bioreaktoren\/","og_locale":"de_DE","og_type":"article","og_title":"Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing","og_description":"Single use plastic bioreactors (SUBs) have become a viable alternative for bioreactor processing. Improved sanitation, lower costs, and more.","og_url":"https:\/\/www.alicat.com\/de\/artikel\/einweg-bioreaktoren\/","og_site_name":"Alicat Scientific","article_publisher":"https:\/\/www.facebook.com\/alicatscientific\/","article_published_time":"2021-05-31T08:26:00+00:00","article_modified_time":"2025-09-25T20:54:28+00:00","og_image":[{"width":768,"height":512,"url":"https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/alicat-bioprocessing-2-768x512-1.webp","type":"image\/webp"}],"author":"Alicat Scientific","twitter_card":"summary_large_image","twitter_misc":{"Written by":"Alicat Scientific","Est. reading time":"3\u00a0Minuten"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"WebPage","@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/","url":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/","name":"Vorteile von Einweg-Kunststoff-Bioreaktoren f\u00fcr die Bioprozessierung im kleinen Ma\u00dfstab - Alicat Scientific","isPartOf":{"@id":"https:\/\/www.alicat.com\/#website"},"primaryImageOfPage":{"@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/#primaryimage"},"image":{"@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/#primaryimage"},"thumbnailUrl":"https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/alicat-bioprocessing-2-768x512-1.webp","datePublished":"2021-05-31T08:26:00+00:00","dateModified":"2025-09-25T20:54:28+00:00","description":"Einweg-Bioreaktoren aus Kunststoff (SUBs) sind zu einer praktikablen Alternative f\u00fcr die Bioreaktorbearbeitung geworden. Bessere Hygiene, niedrigere Kosten und mehr.","breadcrumb":{"@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/#breadcrumb"},"inLanguage":"de","potentialAction":[{"@type":"ReadAction","target":["https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/"]}]},{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/#primaryimage","url":"https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/alicat-bioprocessing-2-768x512-1.webp","contentUrl":"https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/alicat-bioprocessing-2-768x512-1.webp","width":768,"height":512,"caption":"Bioprocessing mass flow controller"},{"@type":"BreadcrumbList","@id":"https:\/\/www.alicat.com\/articles\/single-use-bioreactors\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/www.alicat.com\/"},{"@type":"ListItem","position":2,"name":"Advantages of Single-Use Plastic Bioreactors in Small-Scale Bioprocessing"}]},{"@type":"WebSite","@id":"https:\/\/www.alicat.com\/#website","url":"https:\/\/www.alicat.com\/","name":"Alicat Scientific","description":"Alicat Scientific | Schnellstm\u00f6gliche Durchflussmessung","publisher":{"@id":"https:\/\/www.alicat.com\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/www.alicat.com\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"de"},{"@type":"Organization","@id":"https:\/\/www.alicat.com\/#organization","name":"Alicat Scientific","alternateName":"Alicat","url":"https:\/\/www.alicat.com\/","logo":{"@type":"ImageObject","inLanguage":"de","@id":"https:\/\/www.alicat.com\/#\/schema\/logo\/image\/","url":"","contentUrl":"","caption":"Alicat Scientific"},"image":{"@id":"https:\/\/www.alicat.com\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/alicatscientific\/","https:\/\/linkedin.com\/company\/alicat-scientific-inc","https:\/\/www.youtube.com\/channel\/UCPPX4sBOO2eEu65Zn-EfwCw"],"email":"info@alicat.com","telephone":"+18882906060","legalName":"Alicat Scientific, Inc."}]}},"_links":{"self":[{"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/posts\/41732","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/users\/7"}],"replies":[{"embeddable":true,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/comments?post=41732"}],"version-history":[{"count":0,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/posts\/41732\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/media\/39532"}],"wp:attachment":[{"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/media?parent=41732"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/categories?post=41732"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.alicat.com\/de\/wp-json\/wp\/v2\/tags?post=41732"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}