{"id":41763,"date":"2024-06-05T19:31:31","date_gmt":"2024-06-05T19:31:31","guid":{"rendered":"https:\/\/www.alicat.com\/?page_id=41763"},"modified":"2026-02-11T22:58:23","modified_gmt":"2026-02-11T22:58:23","slug":"durchflussmesser-fur-die-bioprozesstechnik","status":"publish","type":"page","link":"https:\/\/www.alicat.com\/de\/industries\/bioreactor-fermentation\/flow-meters-for-bioprocessing\/","title":{"rendered":"Rotameter vs. Durchflussmessger\u00e4te f\u00fcr die Bioprozesstechnik"},"content":{"rendered":"\n[et_pb_section fb_built=”1″ _builder_version=”4.24.2″ _module_preset=”default” background_image=”https:\/\/www.alicat.com\/wp-content\/uploads\/2024\/04\/AdobeStock_353086569_Worker_heavy_industrial_factory_machine_production_line-scaled-1.webp” width_tablet=”” width_phone=”auto” width_last_edited=”on|phone” max_width=”100%” min_height=”325px” max_height_tablet=”” max_height_phone=”229px” max_height_last_edited=”on|phone” custom_margin=”-80px|||||” custom_margin_tablet=”-80px|||||” custom_margin_phone=”-60px|0px||0px|false|true” custom_margin_last_edited=”on|phone” module_alignment_tablet=”” module_alignment_phone=”left” module_alignment_last_edited=”on|phone” locked=”off” global_colors_info=”{}” custom_css_main_element_last_edited=”on|phone”][\/et_pb_section][et_pb_section fb_built=”1″ admin_label=”Section” _builder_version=”4.23.1″ _module_preset=”default” locked=”off” global_colors_info=”{}”][et_pb_row _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”-40px||||false|false” hover_enabled=”0″ global_colors_info=”{}” custom_margin_last_edited=”on|phone” sticky_enabled=”0″ custom_margin_phone=”-20px||||false|false” custom_margin_tablet=”-40px||||false|false”][et_pb_column type=”4_4″ _builder_version=”4.23.1″ _module_preset=”default” global_colors_info=”{}”][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||||false|false” custom_padding=”||10px||false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]

Bioprocessing: Rotameters vs. thermal flow meters vs. laminar DP flow meters<\/h1>\nAny bioprocess needs flow meters to feed bioreactors, drive filtration and chromatography, and monitor critical process parameters. Here we provide a comparison of the operating principles and key features of three flow meter technologies: rotameters, MEMS thermal mass flow meters, and laminar DP mass flow meters. We then provide recommended use cases for each technology in bioprocessing applications.\n

Rotameter operating principle<\/h2>\nRotameters measure volumetric flow rate<\/a> using the variable area principle. A rotameter consists of a float inside a tapered tube, and the upward force of a fluid passing through the tube dictates the position of the float. This creates a set operating range: the upward force of the fluid is a function of flow rate and density. The float rises and falls linearly with the volumetric flow passing through the meter. This relationship is valid only at the pressure and fluid of the rotameter was calibrated for. It rises as the velocity head and buoyancy of the fluid passing through the meter increase (it is worth noting that buoyancy is primarily relevant for liquids, as it is negligible for gases). As the force of the fluid equalizes with the downward force of gravity, the float reaches a steady state and provides a stable flow measurement. The volumetric flow represents the volume of gas flowing through the system per unit time (e.g. liters per minute).\n

MEMS thermal meter operating principle<\/h2>\nMEMS (micro-electromechanical systems) thermal flow meters use thermal heating elements, temperature sensors, and thermal properties of a gas to measure mass flow rates. There are two ways to utilize this setup: directly in the main flow path, or in a bypass tube. BASIS MEMS thermal mass flow meters<\/a> measure flow directly in the flow path.\n\nMEMS calorimetric sensors measure mass flow rates<\/a> with symmetrical thermopiles upstream and downstream of the heating element. Power is provided to the heating element to keep the temperature differential constant. When there is no flow, the sensors read the same value. When gas is flowing, the heated gas travels downstream, and the downstream sensor will be hotter than the upstream sensor.\n\n

Laminar differential pressure (DP) flow meter operating principle<\/h2>\nThese mass flow meters<\/a> measure differential pressure across a flow body<\/a>. This reading is converted into a volumetric flow rate using the Hagen-Poiseuille equation. Finally, the mass flow rate<\/a> is calculated <\/span>using the volumetric flow rate and instantaneous fluid temperature and absolute pressure.[\/et_pb_text][et_pb_video src=”https:\/\/www.youtube.com\/embed\/Yp7hRo7clUs&?rel=0#8221; _builder_version=”4.27.4″ _module_preset=”default” module_alignment=”center” hover_enabled=”0″ sticky_enabled=”0″ custom_padding=”||||false|false” custom_margin=”2rem||2rem||true|false” width=”80%” width_last_edited=”on|phone” width_phone=”100%” width_tablet=”80%”][\/et_pb_video][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” hover_enabled=”0″ sticky_enabled=”0″ custom_margin=”||1rem||false|false”]

Whereas volumetric flow represents the volume of gas flowing through a system, mass flow represents the number of flowing gas particles. This is important because gases are compressible and gas volume changes with temperature and pressure conditions, while mass does not. Mass flow meters therefore allow flow rates to be measured and compared across a variety of process conditions. Mass flow is either displayed as a standardized volumetric flow (e.g. standard liters per minute) or a \u201ctrue\u201d mass flow in weight per time (e.g. grams per minute).<\/p>\n

Feature comparison<\/h2>\n

The following table compares key features (technical and otherwise) of rotameters, laminar DP mass flow meters, and thermal flow meters.<\/p>[\/et_pb_text][dvmd_table_maker tbl_column_max_width=”1.1fr” tbl_responsive_break_by=”row” tbl_frame_type=”lines” tbl_frame_line_style=”none” tbl_frame_line_color=”#A2AAB6″ tbl_frame_line_width=”0px” tbl_tcell_cell_color=”#eaeaea” tbl_tcell_cell_padding=”14px|50px|14px|50px|true|true” tbl_rhead_cell_color=”#EAEAEA” _builder_version=”4.27.4″ _module_preset=”default” tbl_tcell_text_line_height=”2em” hover_enabled=”0″ border_radii=”on|16px|16px|16px|16px” border_width_all=”0px” border_width_all_tbl_tcell_cell_border=”0px” border_color_all_tbl_tcell_cell_border=”#597084″ global_colors_info=”{}” custom_margin=”||2rem||false|false” sticky_enabled=”0″ tbl_row_header_count=”0″ tbl_chead_cell_color=”#eaeaea”][dvmd_table_maker_item col_content=”\nOperating range\nCommunication & data logging\nVariable outputs\nCustomization\nIntegration\nFlexibility\nCost” col_column_max_width=”0.8fr” col_tcell_cell_color=”#EAEAEA” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_font=”|700|||||||” col_tcell_text_text_color=”#597084″ col_tcell_text_letter_spacing=”0px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”#597084″ border_style_all_col_tcell_cell_border=”solid” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”Rotameter<\/b>\nAverage 50:1\nManual (read and record)\nVolumetric flow rate\nLimited customization\nSimple installation\n

  • Gas meters not damaged by liquids<\/li>
  • No power requirements<\/li>
  • Parts commonly available<\/li><\/ul>\n$” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”MEMS thermal flow meter<\/b>\nUp to 1,000:1\nAnalog, serial communication, and\/or Modbus RTU\nMass flow rate and temperature\nAvailable in manifold\nEasy incorporation with system equipment & data systems\n
    • Small footprint<\/li>
    • Calibration\/repairs done at Alicat<\/li><\/ul>\n$$” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”Laminar DP flow meter<\/b>\nUp to 10,000:1\nDigital display, analog I\/O, serial communication, and\/or industrial protocols\nMass flow rate, volumetric flow rate, pressure, and temperature\nAll units custom designed to application needs\nEasy incorporation with system equipment & data systems\n
      • Gas meters can handle process backsplash<\/li>
      • Require power supply<\/li>
      • Calibration\/repairs done at Alicat<\/li><\/ul>\n$$$” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][\/dvmd_table_maker][et_pb_text _builder_version=”4.27.4″ _module_preset=”default” custom_margin=”||1rem||false|false” hover_enabled=”0″ global_colors_info=”{}” sticky_enabled=”0″]

        <\/h2>\n

        Device recommendations for bioprocessing applications<\/h2>\n

        Rotameters offer simplicity and low costs, while Alicats are likely advantageous to bioprocessing environments optimizing for process analytical technology (PAT) or Pharma 4.0. This table below contains device recommendations for your bioprocess flow meters based on your process development priorities.<\/p>[\/et_pb_text][dvmd_table_maker tbl_row_header_count=”0″ tbl_column_max_width=”1.1fr” tbl_responsive_break_by=”row” tbl_frame_type=”lines” tbl_frame_line_style=”none” tbl_frame_line_color=”#A2AAB6″ tbl_frame_line_width=”0px” tbl_tcell_cell_color=”#eaeaea” tbl_tcell_cell_padding=”14px|50px|14px|50px|true|true” tbl_rhead_cell_color=”#EAEAEA” _builder_version=”4.25.1″ _module_preset=”default” tbl_tcell_text_line_height=”2em” tbl_chead_text_text_color=”#FFFFFF” hover_enabled=”0″ border_radii=”on|16px|16px|16px|16px” border_width_all=”0px” border_width_all_tbl_tcell_cell_border=”0px” border_color_all_tbl_tcell_cell_border=”#597084″ global_colors_info=”{}” sticky_enabled=”0″][dvmd_table_maker_item col_content=”Priority<\/b>\nPrecision\nIntegration & automation\nScalability\nEase-of-use\nPricing\nFDA compliance” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”Recommended device<\/b>\nAlicat flow meter\nAlicat flow meter\nAlicat flow meter\nRotameter\nRotameter\nSituation-dependent” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][dvmd_table_maker_item col_content=”Reason<\/b>\nTight tolerances across a wide operating range, with digital recording and communication for precise process control.\nAnalog and serial communication protocols, including industrial protocols (EtherNet\/IP, DeviceNet, Modbus, PROFIBUS, PROFINET, etc.).\nHigher operating range allows a single device to monitor a much wider range of flows.\nSimple installation, repeatability, and accuracy, with parts available off-the-shelf for any repairs or servicing.\nLower-cost devices available.\n

        • Rotameters are advantageous because of their simplicity: they are mechanical devices which do not store or transmit data, and are not integrated with other data systems.<\/li>
        • Alicat devices can better meet the PAT directive, but increased complexity brings increased regulatory oversight.<\/li><\/ul>” col_tcell_cell_color=”rgba(234,234,234,0.51)” _builder_version=”4.25.1″ _module_preset=”default” col_tcell_text_text_color=”#597084″ col_tcell_text_font_size=”14px” border_width_all_col_tcell_cell_border=”0px” border_color_all_col_tcell_cell_border=”RGBA(255,255,255,0)” border_width_bottom_col_tcell_cell_border=”1px” border_color_bottom_col_tcell_cell_border=”rgba(162,170,182,0.45)” border_style_bottom_col_tcell_cell_border=”solid” border_width_all_col_rhead_cell_border=”0px” global_colors_info=”{}”][\/dvmd_table_maker_item][\/dvmd_table_maker][\/et_pb_column][\/et_pb_row][\/et_pb_section]\n","protected":false},"excerpt":{"rendered":"

          Bioprocessing: Rotameters vs. thermal flow meters vs. laminar DP flow meters Any bioprocess needs flow meters to feed bioreactors, drive filtration and chromatography, and monitor critical process parameters. Here we provide a comparison of the operating principles and key features of three flow meter technologies: rotameters, MEMS thermal mass flow meters, and laminar DP mass […]<\/p>\n","protected":false},"author":7,"featured_media":39695,"parent":46365,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_et_pb_use_builder":"on","_et_pb_old_content":"","_et_gb_content_width":"","content-type":"","_searchwp_excluded":"","footnotes":""},"page-categories":[],"class_list":["post-41763","page","type-page","status-publish","has-post-thumbnail","hentry"],"acf":[],"yoast_head":"\nRotameters vs Flow Meters for Bioprocessing - Alicat Scientific<\/title>\n<meta name=\"description\" content=\"Rotameters, thermal meters and laminar DP flow meters have different use cases. This article breaks down their operating principles, advantages, and ideal applications.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.alicat.com\/de\/branchen\/bioreaktor-fermentation\/durchflussmesser-fur-die-bioprozesstechnik\/\" \/>\n<meta property=\"og:locale\" content=\"de_DE\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Rotameters vs Flow Meters for Bioprocessing\" \/>\n<meta property=\"og:description\" content=\"Rotameters, thermal meters and laminar DP flow meters have different use cases. 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